Precision Targeting Platform

Bondics
Therapeutics

Target. Stratify. Act.
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01 — Overview

Precision Targeting Platform
for Oncology and Senescence

We develop integrated therapeutic and diagnostic technologies—including immune engagers, targeted radiotracers, and next-generation binding scaffolds—to detect, stratify, and eliminate disease-driving cells.

A Multimodal Precision Strategy Platform.
01

Immune Engagers

Targeted NK cell recruitment for selective elimination of disease-driving cell populations.

02

Radiotracers

Diabody-based molecular imaging for precision tumor detection and patient stratification.

03

Bicyclic Peptides

Conformationally constrained scaffolds with enhanced tissue penetration and target affinity.

The Problem

Complex Disease.
Insufficient Tools.

Cancer and age-related diseases are driven by heterogeneous cell populations resistant to conventional detection and elimination strategies.

Poor patient stratification
Incomplete target engagement
Limited tissue penetration
Fragmented therapeutic approaches
Our Solution

An Integrated Precision
Targeting Platform

We combine complementary technologies into a unified framework that addresses detection, stratification, and elimination.

DETECTRadiotracers validate and quantify target expression in vivo
STRATIFYPatient selection optimized for targeted therapeutic intervention
ELIMINATETriKEs drive immune-mediated clearance of target-positive cells
Lead Program

TRK-001 — First-in-Class Tri-specific Killer Engager

Designed to selectively eliminate disease-driving senescent cells with high precision and sustained immune activation.

View Pipeline →
02 — Science & Technology

An Integrated Targeting Platform

Our platform integrates immune effector recruitment, target-specific binding, and diagnostic imaging to enable mechanistically driven therapeutic development.

A

Tri-specific Killer Engager (TriKE) Module

Engineered fusion proteins that bridge NK cells to disease-associated surface antigens, inducing potent and sustained cytotoxic responses.

Architecture
CD16-binding domainEngages FcγRIIIa on NK cells
Target-binding domainRecognizes disease-associated surface antigens
Cytokine moduleDrives NK cell proliferation, persistence, and activation
Rationale
NK cells provide rapid cytotoxic responses without antigen priming
Reduced cytokine release risk relative to T-cell therapies
Potential for off-the-shelf biologic formats
B

Radiotracer (Diabody-Based Imaging) Module

Engineered diabody fragments for targeted molecular imaging enabling non-invasive quantification of target expression across tumor compartments.

Architecture
Bivalent antigen bindingHigh-affinity engagement of target antigens
Reduced molecular sizeOptimized pharmacokinetics vs. full IgG
Imaging applicationsPET/SPECT-compatible formats for clinical translation
Rationale
Non-invasive quantification of target expression in vivo
Enables patient selection for targeted therapies
Monitors treatment response longitudinally
C

Bicyclic Peptide Module

Conformationally constrained scaffolds engineered for high-affinity target binding with superior tissue penetration and protease resistance.

Architecture
Small molecular sizeEnhanced tumor and tissue penetration
High stabilityProtease resistance in biological environments
Versatile formatApplicable as ligands, conjugates, or imaging agents
Rationale
Expanded targeting options beyond antibody modalities
Compatibility with drug conjugate and theranostic formats
Synergistic with TriKE and radiotracer programs
Platform Integration

One integrated platform with three modality engines.

DETECTSTRATIFYELIMINATE
03 — Pipeline

A Multi-Modal Precision Pipeline

Integrating detection, stratification, and elimination into a single development framework across three complementary programs.

Program
Modality
Discovery
Preclinical
Phase I
Phase II
Phase III
TRK-001
Oncology / Senescence
TriKE
RT-101
Oncology
Radiotracer
BCP-201
Oncology
Bicyclic Peptide
COMPLETED / ACTIVE
UPCOMING

Advance TRK-001

Progress lead TriKE program toward IND filing with preclinical package.

Optimize RT-101

Refine radiotracer pharmacokinetics and imaging window for clinical translation.

Expand BCP Library

Broaden bicyclic peptide targeting to additional oncology and senescence antigens.

04 — Applications

Transforming Disease Treatment
Through Precision Targeting

Heterogeneous tumor targeting

Oncology

Targeting complex, antigen-heterogeneous tumors with high specificity through integrated detection, stratification, and immune-driven elimination strategies.

+Tumor antigen-specific TriKE programs
+Radiotracer-guided patient stratification
+Multi-modal combination approaches
Pathological cell elimination

Fibrosis & Senescence

Eliminating senescent and fibrogenic cell populations that drive chronic disease progression and tissue dysfunction across multiple organ systems.

+Selective senolytic immune engagement
+Non-invasive senescent cell burden imaging
+Disease modification in aging-related conditions
Novel modality development

Next-Gen Therapeutics

Enabling entirely new therapeutic modalities through advanced targeting scaffolds, multispecific formats, and theranostic platform development.

+Bicyclic peptide–drug conjugates
+Multispecific biologic formats
+Theranostic platform integration
Bondics Therapeutics
Target. Stratify. Act.
05 — Team

Built by Experts in Immunology
and Molecular Engineering

Our team brings together deep expertise across immunology, protein engineering, and translational medicine, supported by advisors with experience in oncology, aging science, and drug development.

Pantalee Chuensampan
Co-Founder
Pantalee Chuensampan
MD
CEO
Kiattawee Choowongkomol
Co-Founder
Kiattawee Choowongkomol
PhD
CTO
Aussara Panya
Co-Founder
Aussara Panya
PhD
Lueacha Tabtimmai
Co-Founder
Lueacha Tabtimmai
PhD
Areas of Expertise
Immunology & NK cell biology
Protein engineering & biologics
Translational medicine
Drug development & clinical strategy
Oncology & aging science
Mission

“To develop precision targeting platforms that redefine the treatment of complex diseases.”

Get in Touch
06 — Contact

Partner With Us

We are open to exploring additional collaboration opportunities aligned with our platform.

Start a Conversation
We Partner Across:
+Biopharmaceutical collaborations
+Molecular imaging and theranostics
+Platform licensing and co-development
+Strategic investment

Want to join our team ? Please send us a message !

Contact
Where we are:111/1 Charansanitwong 92, Bang O,
Bang Phlat, Bangkok, Thailand 10700